When suffering from a severe muscle cramp, ibuprofen helps ease the discomfort, according to Healthline. A nonsteroidal anti-inflammatory such as Advil or Motrin lessens the muscle cramp as it is happening. For immediate relief, stretch the leg after taking ibuprofen to work out the cramp.
If severe muscle cramps are experienced often, it helps to drink more water or beverages with electrolytes, such as Gatorade, explains Healthline.
Stretching regularly before any strenuous activity and exercise and taking a daily multivitamin also reduce the risk of having severe muscle cramps, notes HealthLinkBC. If a person feels he is experiencing muscle cramps more than usual, he needs to contact his doctor.