When the adrenal glands do not secrete sufficient amounts of cortisol, it can lead to Addison's disease, states MedicineNet. Cortisol is a hormone that has many different functions in the body, such as regulating both blood pressure and heart function and controlling inflammation in the body. The causes of the adrenal glands producing low levels of cortisol can include an attack of the immune system on these organs and infections.
When the immune system of the body damages the adrenal glands, it is connected to some type of immune disease, states the National Institutes of Health's MedlinePlus. The adrenal glands are found above the kidneys, and they consist of two parts called the medulla and cortex. Damage to the cortex of these glands leads to hyposecretion of cortisol which in turn causes Addison's disease.
Some symptoms of this medical condition are diarrhea, feeling tired, pale skin and appetite loss. Addison's can be treated with corticosteroid medications, according to MedlinePlus.