During a flexible cystoscopy, men may feel discomfort when the physician inserts the cystoscope into the urethra and bladder, and they may feel a minor pinching sensation if the physician takes a biopsy, states WebMD. For two days, patients may experience urethral soreness and a burning sensation when urinating.
As of 2015, studies show that patients experience the most pain during a flexible cystoscopy when the cystoscope passes through the urethra, registering an average pain score of 2.82 on a scale of 1 to 10. Pain scores ranged from 0.14 to 0.33 at other times during the procedure, notes the National Center for Biotechnology Information. When the cystoscopy takes place in a doctor's office, patients who can see the procedure on a video screen as it occurs experience approximately 40 percent less pain than patients who cannot see the procedure.