Most of the available research into homeopathic products for gastric reflux centers around Iberogast, which blends nine different herbs, and some studies have shown it to be effective for heartburn and other symptoms, according to WebMD. However, people with gastroesophageal reflux disease should avoid it becuase it contains peppermint oil.
As of 2015, only scant research exists into herbal treatments for heartburn beyond Iberogast. In addition to peppermint oil, Iberogast also contains milk thistle, licorice, lemon balm, greater celandine and chamomile as well as clown's mustard plant, caraway and angelica. While nausea, cramping, stomach pain and heartburn all abate for many who take this, the peppermint oil is a risk factor, as stated by WebMD.
Melatonin, a supplement for sleep, has also been recommended for treatment of heartburn, but the research remains mixed about its effectiveness. Another supplement that people use is calcium. As the active ingredient in many over-the-counter antacids, calcium has a long track record of helping with reflux. However, if antacids are not keeping heartburn and reflux from happening after a regimen of more than two weeks, medical attention is necessary, as the patient has a risk of gastroesophageal reflux disease, or GERD. This often leads to long-term swelling and restrictive structures in the esophagus and, in rare cases, leads to cancer if the reflux is not treated, reports WebMD.