A home remedy that sometimes helps in getting rid of thick, yellow nails is applying Vick's VapoRub directly on the nail, according to Mayo Clinic. Simply use a cotton swab, and cover the nail in VapoRub every day.
Another home remedy that often helps with the pain associated with thick, yellow nails is trimming the nails using nail clippers or a file, according to Mayo Clinic. In order to use this treatment, the nails must first be softened. To do this, simply apply urea cream to the nails at night, and cover them with a bandage. The next morning, remove the bandage, and wash off the cream with soap and water. Repeat until the nail softens.