Supplements most likely to work when treating enlargement of the prostate include beta-sitoseterols and pygeum, according to WebMD. Rye grass pollen extract and African wild potato, which is also known as South African star grass, may also help.
Studies on rye grass pollen extract indicate that it may help bladder muscles contract or relax the tubes responsible for urine flow, reports WebMD. This may reduce the size of the prostate and diminish the need to get up during the night to urinate. Research also suggests that African wild potato may help to ease urinary symptoms associated with an enlarged prostate.