There are multiple differences between hepatitis genotype one and two, such as the length of treatment required, the response to treatment and the percentage of infections, states Centers for Disease Control. For example, hepatitis genotype one accounts for 75 percent of all infections in America.
In total there are six specific genotypes and 50 subtypes of the hepatitis C virus, according to the Centers for Disease Control. Patients with the hepatitis genotype two often respond better to treatment than patients with genotype one. Most often, genotype two only requires 24 weeks of treatment, rather than the 48 required for genotype one. Generally, the specific genotype does not play a significant role in the progression of liver disease. Fifteen to 25 percent of infected patients clear the infection from their bodies without treatment.
Genotyping is important because it allows doctors to prescribe combination therapies for patients, asserts the Centers for Disease Control. Once a genotype is diagnosed, it does not need to tested again, as the genotype does not change. Some diseases not related to the liver may develop as a result of a hepatitis C infection. Diabetes, abnormal proteins in the blood, kidney disease caused by inflammation and possibly non-Hodgkin's lymphoma occur more often in hepatitis C patients.