When men take Midol, they may experience relief from pain, according to Reference.com. While marketed as a treatment for PMS symptoms in women, Midol contains acetaminophen, according to its manufacturer, Bayer Healthcare; all formulations of the medication treat headache, backache and muscle aches.
An article in the Toronto Star explains that acetaminophen is an analgesic that helps minimize the body's response to pain. Midol also contains caffeine, which is a stimulant, and pyrilamine maleate, an antihistamine. These ingredients contained in Midol are meant to relieve bloating, fatigue and swelling caused by water retention in women experiencing PMS symptoms. The Toronto Star article quotes a drug information pharmacist who assures that none of those ingredients make men less masculine.