Barrett's esophagus is a serious but asymptomatic complication of gastroesophageal reflux disease, explains WebMD. The symptoms of gastroesophageal reflux disease include irritation of airways that worsens asthma symptoms, but fatigue is not a direct result of Barrett's disease or GERD.
Ten percent of patients with GERD go on to develop Barrett's esophagus, according to WebMD. This condition occurs when cells that make up the lining of the esophagus slowly change until they resemble the lining of the intestines instead. This disease increases the risk of developing esophageal adenocarcinoma, a fatal cancer of the esophagus, but WebMD explains that only 1 percent of cases of Barrett's esophagus progress into cancer.