A person with factor V blood disorder (Factor V Leiden), which is a form of thrombophilia, has an inherited mutation that causes abnormal blood clotting that can lead to blocked blood vessels, according to Mayo Clinic. Many who have factor V blood disorder do not end up having clotting issues, but the condition can become serious and life threatening. Although both men and women can have factor V blood disorder, women with the mutation should be especially careful to supervise their blood clotting issues during pregnancy or when taking estrogen supplements.
Those who have inherited the Factor V Leiden mutation are more likely to suffer from deep vein thrombosis (DVT), which commonly causes blood clots, discomfort and joint pain in the legs, as stated by the U.S. National Library of Medicine. Having Factor V Leiden thrombosis can also increase the chances that a blood clot will be released within the veins and move throughout the body. This can cause larger problems. For instance, a moving blood clot can get stuck in the lungs, leading to a pulmonary embolism. While these blood clot issues can be serious and life threatening, only a small percentage (about 10 percent) of people with the Factor V Leiden mutation actually develop abnormal blood clotting issues.