End stage multiple myeloma is the final stage of advanced multiple myeloma. According to MedlinePlus, the symptoms of end stage multiple myeloma include vomiting, nausea, urination problems, numbness in legs and constipation.
Multiple myeloma often times originates in the bone marrow and is similar to diseases such as leukemia and lymphoma. WebMD states that currently there is no cure for multiple myeloma and that the treatments move slowly in dealing with the disorder. During the early stages of multiple myeloma, no symptoms may be apparent. As the disease begins to move forward, symptoms include weight loss, kidney problems, bone pain due to lytic bone disease, anemia, confusion, excessive thirst from hypercalcemia, and infections. In rare cases, purple masses, known as extramedullary plasmacytomas, can develop beneath the skin.
According to WebMD, risk factors that can make people more vulnerable to multiple myeloma include being male, over 65 years of age, African-American, and having family members who have been afflicted by the disease. Those that have been diagnosed with solitary plasmacytoma, or monoclonal gammopathy of uncertain significance (MGUS), are also at risk for developing mutlple myeloma. During lab tests, indicators of multiple myeloma are anemia, protein in urine, elevated creatine, and high blood calcium.