The most effective topical cream for fungal skin infections is terbinafine, according to PubMed Health. Other topical antifungal creams that treat skin infections include azoles, ciclopiroxolamine, butenafine, tolnaftate and undecanoate.
For fungal skin infections, doctors usually prescribe over-the-counter medications such as ketoconazole or clotrimazole from the class of drugs known as azoles. These do not have serious side effects and are thus preferable compared to other antifungal drugs such as nystatin or amphotericin B, notes Healthline.
Lotrimin and Mycelex are examples of effective 1 percent clotrimazole antifungal creams, according to MedicineNet. Lamisil is an example of an effective 1 percent terbinafine antifungal cream.