Antifungal pills taken orally have the highest success rate when treating hand nail fungus, according to WebMD. Antifungal pills treat moderate-to-severe nail infections that are difficult to treat.
Headaches, stomach issues and skin rash are some of the mild side effects related to oral antifungal medicines, states WebMD. Adverse side effects include kidney and liver dysfunction, heart failure, liver damage or failure, and dangerous reactions to common medicines. Individuals concerned with side effects may opt to use a prescription topical treatment. It may take a year or longer for nail appearance to return to normal after treatment, and fungal nail infections return in many cases. A combination of nail removal with antifungal pills is oftentimes more effective than using one treatment alone.