Nonsteroidal anti-inflammatory medicines, or NSAIDS, may interact with lithium, methotrexate,diuretics, high blood pressure medication, and any medication that increases bleeding. Some of these interactions can be dangerous, while others can reduce the benefits of medications, as reported by RxList.
NSAIDS lessen the benefits of diuretics by increasing blood flow to the kidneys. This increased blood flow to the kidneys can cause a reduction in the elimination of lithium or methotrexate, which can increase their side effects. NSAIDS also lessen the body's ability to clot the blood. When combined with other drugs that also increase the risk of bleeding, NSAIDS can present serious bleeding risks, says MedicineNet.com. NSAIDS may also cause an increase in blood pressure, which can counteract the benefits of medicine taken for hypertension.
NSAIDS are effective in reducing inflammation by lessening the amount of prostaglandins produced in the body, according to RxList. These chemicals increase pain and inflammation in the body, but they are also responsible for producing blood platelets that lead to blood clotting, protecting the stomach and intestines from acid, and ensuring that the kidneys function normally. By decreasing the production of prostaglandins, NSAIDS cause a reduction in inflammation, but they also lead to a reduction in other beneficial functions provided by the chemicals.