The aloe plant produces two substances: gel and latex, says WebMD. Aloe gel taken by mouth is likely safe, although side effects have been linked to taking aloe latex by mouth.
Aloe gel when taken by mouth is potentially helpful in treating osteoarthritis and inflammation, reports WebMD; however, aloe latex may be present in aloe gel products. Taking aloe latex by mouth is contraindicated for those with intestinal conditions, as it is a bowel irritant and could irritate hemorrhoids. Aloe latex taken by mouth is linked to kidney failure, and taking 1 gram per day for several days can be fatal. Both aloe gel and latex lower blood sugar levels, so those with diabetes are advised to monitor their blood sugar levels closely when taking aloe vera by mouth.