Excedrin Migraine's recommended dosage for adults ages 18 and older is two caplets with a full glass of water, notes the manufacturer's website. Children under the age of 18 should not take Excedrin Migraine without speaking with a doctor.
Excedrin Migraine's active ingredients include acetaminophen, aspirin and caffeine; adults allergic to or taking other drugs containing these ingredients should consult a doctor before taking Excedrin Migraine. Those taking this medication should avoid consuming alcohol, warns Drugs.com. Taking more than two caplets of Excedrin Migraine within a 24-hour period can lead to toxicity. Adults with existing health conditions such high blood pressure or liver problems should speak with a doctor before taking Excedrin Migraine.