What Are the Dosage Guidelines for Linzess?


Quick Answer

The recommended dosage when taking Linzess for irritable bowel syndrome with constipation is 290 micrograms once a day on an empty stomach, according to Drugs.com. When taking it for chronic idiopathic constipation, the recommended dose is 145 micrograms once a day. Linzess is to be taken on an empty stomach.

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Full Answer

Linzess is an oral medication that relieves the symptoms associated with irritable bowel syndrome with constipation and chronic idiopathic constipation, or CIC, says Ironwood Pharmaceuticals. It is not recommended in children between 6 and 17 years old. During the study of the drug, some juvenile mice had adverse effects and deaths, though no adult mice experienced the same effects.

Among the different adverse effects of taking Linzess, diarrhea was the most common, notes Ironwood Pharmaceuticals. This occurred in patients with both conditions in placebo trials. There was moderate to severe diarrhea, with severe diarrhea occurring in about 2 percent of people taking Linzess. Patients experiencing diarrhea are instructed to stop taking the drug and inform their doctor before continuing with treatment.

Other potential side effects of taking the drug were headaches, abdominal distension, flatulence, gastroenteritis and abdominal pain, explains Ironwood Pharmaceuticals. Patients taking it for CIC also experienced sinusitis and upper respiratory tract infection.

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