Disordered proliferative endometrium is a result of an anovulatory cycle that lacks ovulation and leads to high levels of estrogen from low progesterone levels. The University of Virginia School of Medicine describes anovulation as the absence of ovulation during the reproductive years, not including pregnancy, and is the most common cause of dysfunctional uterine bleeding. Anovulation commonly occurs at menarche and at menopause.Continue Reading
The exact cause of anovulation is not fully understood, according to the University of Virginia School of Medicine. In the absence of progesterone, the spiral arterioles do not develop properly. Once estrogen levels decline, there is a loss of stromal fluid and potential break-through bleeding occurs. However, in some cases when there is no drop in estrogen levels, bleeding can still occur because the necessary blood flow to the proliferative endometrium is not steady.
In a histological test, doctors can determine that there is estrogen stimulation but no progesterone production. When endometrial glands are proliferative, a histology report shows changes in the shape and structure, which are subtle. One of these mild changes is cystic dilation. When the stroma is broken down, pieces of isolated glands do not secrete, notes the University of Virginia School of Medicine.Learn more about Reproductive Anatomy
Ovarian follicles store female egg cells and produce the reproductive hormones estrogen and progesterone, the Mayo Clinic states. Follicles grow every month, and during a woman's menstrual cycle a mature egg is released for potential fertilization.Full Answer >
Thickening of the uterus lining, or endometrial hyperplasia, is usually caused by too much estrogen without progesterone, according to the American Congress of Obstetricians and Gynecologists. This hormonal imbalance occurs when a woman does not ovulate.Full Answer >
Thickening of the endometrial lining is caused when there is an excess of the hormone estrogen without the corresponding female hormone, progesterone, states Healthline. When this occurs it is known as endometrial hyperplasia.Full Answer >
The causes of uterine thickening include imbalance and lack of control of estrogen and progesterone hormones, and chronic diseases such as diabetes, obesity and polycystic ovarian syndrome, according to Healthgrades. Hormone imbalances caused by these diseases, or in general, can make cells on the uterus lining grow and thicken.Full Answer >