Swollen and hot hands and feet, or erythromelalgia, is a condition that can be inherited, or it may result from disorders of the bone marrow or the nerves, says the National Organization for Rare Disorders. It can also be the side effect of some medications. Familial cases of erythromelalgia suggest an autosomal dominant disorder. This means that a gene from one of the parents overwhelmed the normal gene and caused the disease to manifest.
The bone marrow conditions associated with erythromelalgia are usually myeloproliferative disorders, claims NORD. Myeloproliferative disorders are those that cause the bone marrow to make blood cells that are abnormal in some way, says the University of Maryland Medical Center. The cells can be red blood cells, white blood cells or platelets. There is also a myeloproliferative disorder, in which the bone marrow makes too much collagen.
Some people also experience symptoms associated with peripheral neuropathy when they have flare-ups of erythromelalgia, states NORD. Peripheral neuropathy is a disorder of the patient's peripheral nerves, which branch out from the spinal cord and control motion and the senses. They also control the nerves involved with involuntary functions, such as blood pressure and heart rate. Other conditions associated with erythromelalgia include Raynaud's disease, in which the extremities become suddenly cold and numb, and lupus erythematosus, an autoimmune disease in which the body attacks the patient's connective tissue.