Multiple sclerosis, peripheral vascular disease, radiculopathy, polio and Buerger's disease are among the diseases that sometimes cause leg pain as part of their symptomology, says Healthline. Leg pain is also caused by conditions such as malignant bone tumors, varicose veins, arthritis, gout and atherosclerosis.
Multiple sclerosis is a chronic disease that strikes the nervous system, causing a range of symptoms potentially leading to total disability, explains Healthline. Peripheral vascular disease occurs when plaque builds up in arteries that supply blood to the arms and legs. Radiculopathy strikes the nerve roots in the spine and creates numbness and pain that spread outward. Polio is a contagious viral disease that affects the body's nervous system. Blocked blood vessels in the feet and hands that cause pain and tissue damage may be a sign of Buerger's disease.
Serious conditions and injuries that cause leg pain should not be ignored, according to Healthline. Leg pain that is accompanied by swelling, pain that persists or gets worse, the presence of a fever, a pale leg that is cool to the touch, or a leg that is red and warm are all symptoms that require medical attention. Several serious conditions that cause leg pain may lead to may result in severe consequences such as septic arthritis, bone death and impaired growth in children.