There are concerns that taking large doses of creatinine over an extended time can lead to possible side effects, such as muscle cramping and heart, liver and kidney damage. However, there are no clinical studies to date that prove that high doses may cause these side effects, notes WebMD. Another disadvantage is that creatinine may cause weight gain.Continue Reading
Some other possible disadvantages of creatinine use are that it can cause nausea and abdominal pain. This supplement may also interact with caffeine and drugs, such as diuretics and the gout medication probenicid, states the University of Maryland Medical Center.
Creatinine is a supplement used by many athletes to help with performance and to elevate muscle mass. If the recommended doses of creatinine are ingested, then the supplement is thought to be safe, notes WebMD.Learn more about Nutrition & Diets