The British Journal of Clinical Pharmacology reports that prednisolone is a synthetic drug that is also the active metabolite of prednisone, another synthetic drug. Prednisolone is a glucocorticoid that’s primarily used to treat auto-immune and inflammatory conditions, especially in patients with liver disease who are unable to convert prednisone into prednisolone. Prednisone is a corticosteroid that is most often used as an immunosuppressant drug.Continue Reading
Prednisolone has a low level of mineralocorticoid activity, according to Clinical Pharmacokinetics. This property makes prednisolone effective for treating common conditions such as asthma, cluster headaches, rheumatoid arthritis and Crohn’s disease. Physicians also use prednisolone for other inflammatory conditions, such as Bell’s palsy, pericarditis, multiple sclerosis and ulcerative colitis. Rare conditions that may be treated with prednisolone include pyoderma gangrenosum, temporal arteritis and uveitis.
Physicians most often use low doses of prednisone to treat allergic reactions and higher doses to treat some forms of cancer. Prednisone is also a common treatment for laryngitis, myasthenia gravis, rheumaticdisorders, thyroiditis and tuberculosis. Drugs.com reports that prednisone is an effective part of a regimen for preventing tissue rejection after organ transplants. Prednisone's effectiveness as an immunosuppressant also means that susceptibility to infections is a significant side effect of this drug.Learn more about Medications & Vitamins
The best medications used to treat post-nasal drip are steroid nasal sprays such as beclomethasone and oral steroids such as prednisone, according to RxList. Antihistamines may be used as an adjunct or second line of treatment and antibiotics may also be prescribed for treating post-nasal drip.Full Answer >
Common prednisone withdrawal symptoms include severe fatigue, weakness, body aches and joint pain, reports Mayo Clinic. Stopping prednisone after prolonged use can cause adrenal crisis, adds MedicineNet. Symptoms of adrenal crisis include nausea, vomiting and shock, which can be life-threatening. If experiencing withdrawal symptoms, contact a doctor immediately.Full Answer >
A prednisone tapering schedule can be employed by taking a smaller dose of prednisone over a period of time until you finish the medication. It is important to talk to your medical provider before employing the tapering method.Full Answer >
The mechanism of action of prednisone in polymyalgia rheumatica is not well understood, and many believe the efficacy of treatment is related to the anti-inflammatory and immunomodulatory effects of the drug, explains Medscape. Polymyalgia rheumatic responds to low doses of prednisone, and some patients require treatment for several years.Full Answer >