The difference between Lunesta and Ambien is that Lunesta has a longer action in the body and may be effective with patients who want to stay asleep, while Ambien is an extended-release tablet, helping patients stay asleep for a longer duration, explains Healthline. Both of them are sedative-hypnotic drugs.
Lunesta is a brand name for eszopiclone, while Ambien is a brand name for zolpidem, notes Healthline. Both of these medications work by decreasing the brain activity and producing a sense of calm. They are meant for short-term use, and are prescribed for adults with sleeping troubles. Children should not take these medications, since they could experience emotional side effects that are more unpredictable.