Drugs.com indicates a difference in brand names for lansoprazole and omeprazole as well as a difference in who may safely take each drug based on health conditions and possible drug interactions. While lansoprazole falls under the brand names of Prevacid, Prevacid OTC, Prevacid SoluTab and Prevacid I.V., omeprazole commonly comes as FIRST Omeprazole, PriLOSEC, PriLOSEC OTC and Zegerid.
Drugs.com also notes differences in who may or may not take lansoprazole or omeprazole. For instance, the site explains that people who have an electrolyte imbalance or metabolic disorder must not take lansoprazole but makes no such indication for omeprazole. Drugs.com also lists osteoporosis, or low bone mineral density, as a condition under which to avoid omeprazole but does not mention this with regard to lansoprazole. The site also has a much more extensive list of possible drug interactions for lansoprazole, which includes ampicillin, atazanavir, blood thinners such as warfarin, digoxin, diuretics, iron, ketoconazole, methotrexate and theophylline. Drugs.com only lists clopidogrel and HIV or AIDS medications, such as atazanavir, nelfinavir and rilpivirine, as having possible interactions with omeprazole. People who have allergies to omeprazole or any other benzimidazole medications, such as albendazole or mebendazole, must not take omeprazole, but Drugs.com does not make this indication with lansoprazole.