The difference between Claritin and Claritin-D is that the latter is a combination medication containing a decongestant and antihistamine, while Claritin is only an antihistamine. Claritin is an OTC medication that contains loratadine, states RxList. Claritin-D contains loratadine and pseudoephedrine.
Claritin is an OTC medication that is sold under the generic name loratadine, which is the antihistamine and active ingredient in this product. It is available in tablet and syrup form. The tablet has 10.0 milligrams of micronized loratadine, while the syrup has 1.0 milligram per milliliter, notes RxList.
Claritin-D, which comes as either a 12 hour or 24 hour extended release tablet, is available behind the pharmacy counter. This medication is useful to treat the symptoms of nasal congestion due to colds and allergies, according to Drugs.com.