As of 2015, the U.S. Food and Drug Administration has approved six sugar substitutes, including saccharin, aspartame and sucralose, according to Everyday Health. Other less common sweeteners are neotame, acesulfame K and stevia.
Saccharin, which is commercially sold as Sweet'N Low, is used in many diet foods and soft drinks, reports Everyday Health. It's sold in packets and in bulk for use in cooking and baking. Saccharin was once associated with bladder cancer in rats, but it has been determined by the National Cancer Institute and the FDA that it doesn't pose a risk for humans and is safe for those with types 1 and 2 diabetes.
Aspartame is packaged and sold as Nutrasweet or Equal and is also sold in packets or bulk, explains Everyday Health. It's not considered suitable for cooking because the sweetness is reduced by high temperatures. Aspartame has also been linked to a range of health issues, including headaches, depression and cancer. The FDA, the National Cancer Institute and the American Medical Association have all confirmed aspartame's safety for all three types of diabetes.
Sucralose is commercially sold as Splenda and has been found to be a useful substitute for sugar in baking, according to Everyday Health. Sucralose is somewhat newer than other sweeteners, so no adequate studies have tested its long-term effects. It has been deemed safe for all three diabetes types.