Deplin is a medical supplement that supplies L-methylfolate to patients who cannot get enough folic acid in their diet due to certain genetic conditions and other illnesses, as stated on the official website. Deplin is only used under the supervision of a doctor.
Patients may have low L-methylfolate due to advanced age, inadequate nutrition, smoking, diabetes, excessive alcohol consumption, Crohn's disease, colitis or renal failure, according to the official website. As many as 70 percent of depressed patients possess a genetic abnormality that inhibits the body's ability to break down folate, so L-methylfolate may be prescribed as an accessible form of folate that can be carried by the neurotransmitters. Medications such as methotrexate, warfarin, oral contraceptives and anticonvulsants may interfere with the effects of L-methylfolate.
No common side effects of Deplin have been recorded as of 2015, but some patients may experience an allergic reaction, as stated by Drugs.com. Before taking Deplin, patients should notify their doctors if they have anemia, allergies or low vitamin B-12 levels or if they are pregnant or breastfeeding. Deplin can be consumed with or without food, and patients should never take two doses at one time even if they forget a dose. The safety and effectiveness of Deplin in children is not yet known.