When low doses of ethylenediaminetetraacetic acid, or EDTA, are used in chelation therapy, potential side effects include high blood pressure, headache, rash, low blood sugar and phlebitis, a blood clot accompanied by inflammation, WebMD states. Therapy with high levels of EDTA has caused kidney damage and irregular heartbeats.
Chelation therapy is only approved by the Food and Drug Administration for the treatment of lead poisoning, according to WebMD. Some heath care personnel treat atherosclerosis, coronary artery disease and chronic inflammatory diseases such as lupus and arthritis with chelation therapy. However, as of 2015, research does not indicate that this practice has significant positive effects on these conditions.