Antibiotics can cure gonorrhea, although some strains of gonorrhea are resistant to certain antibiotics as of 2015, according to WebMD. If symptoms of gonorrhea do not improve with treatment, a doctor does a gonorrhea culture to determine if there is bacterial resistance to the antibiotic being taken.
Some antibiotics that cure gonorrhea include quinolones, penicillin, tetracycline and sulfa drugs, notes WebMD. Taking antibiotics early in the course of the infection may completely cure gonorrhea without any complications. Without treatment, however, the infection can spread to other parts of the body. The patient must take prescribed antibiotics exactly as directed, as missing doses or ending the course of medication early can interfere with the intended cure.