Prolonged, high-dosage use of Curamin, a curcumin-based vitamin supplement and pain reliever, causes a number of side effects, including nausea and indigestion. Curcumin use also can result in adverse drug interactions, low blood sugar levels and excessive bleeding in people with certain medical conditions, according to WebMD.
Curamin contains concentrated amounts of curcumin and, as such, it is not recommended for people who are undergoing treatment for other medical conditions, particularly diabetes, gallbladder disease, blood disorders and estrogen-reactive cancers. Curcumin mimics the action of a blood thinner, inhibiting the formation of blood clots in people who have blood disorders or who are about to undergo surgery. Extended, high-dose curcumin use can lead to adverse drug reactions in diabetics, resulting in a critical drop in blood sugar levels, as claimed by Healthline.
Curcumin can exacerbate the symptoms of gallbladder disease as well as certain digestive disorders, particularly gastroesophageal reflux disease, according to WebMD. Pregnant women are also generally advised to avoid Curamin, as concentrated curcumin can increase estrogen levels and lead to premature labor and fetal risk.
When consumed at low levels in food prepared with the spice turmeric, curcumin is considered to be safe and even beneficial, posing little to no risk of side effects, as reported by Healthline. However, if Curamin is ingested in very high doses over a long time, the potential for harmful side effects is much higher.