The best creatine supplement for improving performance is a compound that contains 20 grams per day for five days (called loading), followed by a maintenance dose of 2 or more grams daily, according to WebMD. Users of creatine supplements should drink 64 ounces of water per day.
Creatine is also used to treat heart disease, Parkinson's disease, gyrate atrophy, muscular dystrophy and McArdle disease. Creatine is produced naturally in the body from amino acids, and it is transported to the muscles. Approximately 95 percent of the creatine in the body is concentrated in the skeletal muscles, according to Wikipedia, which explains its relevance to muscle-related diseases.