What could cause high levels of immunoglobin E and elevated AST on a blood test?


Quick Answer

Causes of an elevated AST level include liver cancer, cirrhosis of the liver, hepatitis, muscle trauma and mononucleosis, reports MedlinePlus. An increased total immunoglobulin E level is associated with allergic reactions and some parasitic infections, states the American Association for Clinical Chemistry.

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Full Answer

Aspartate aminotransferase, abbreviated AST, is an enzyme found in the cells of the heart, liver and muscle cells, according to MedlinePlus. A normal AST level ranges from 10 to 34 international units per liter. A higher-than-normal AST level often indicates the presence of liver disease, but it is also associated with heart attack and pancreatitis. When tissue containing AST sustains damage, the AST is released into the bloodstream, explains WebMD. The more damage present, the higher the AST level.

The total IgE test helps diagnose allergies in people with symptoms such as chronic itching, eczema, sneezing, itchy eyes and hives, reports the American Association for Clinical Chemistry. An elevated total IgE level usually indicates an allergy to at least one substance. The allergen-specific IgE test is used to determine the type of allergy present. If someone with allergy symptoms has a normal IgE level, it doesn't necessarily mean she does not have allergies. If it has been a long time since the last exposure to the offending allergen, the IgE level may have had time to return to normal.

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