A burning pain in the leg can be indicative of either superficial thromboplebitis or complex regional pain syndrome, or CRPS. Superficial thromboplebitis is a condition in which there is a blood clot in a vein and symptoms can include pain and swelling in the leg area, reports the Mayo Clinic. Complex regional pain syndrome is a condition that causes chronic pain in the leg or arm regions, explains the National Institutes of Health.
Superficial thromboplebitis may cause a throbbing or burning pain and can often affects a person's sleep, relates the Indiana Hemophilia & Thrombosis Center. A risk factor for this condition can be varicose veins, being older than age 60 and inactivity. Treatment can include medication to dissolve the clot, states the Mayo Clinic.
Although the exact cause of CRPS is not entirely known, it is thought that it may be related to the nervous system damage or an injury in the affected area. Although no cure exists for CRPS, the disease and symptoms may be managed with certain medications and possible surgeries, according to the National Institutes of Health.