According to Drugs.com, the dose of hydrochlorothiazide for hypertension is 25 milligrams orally, once a day. Some patients may need the dosage increased to 50 milligrams. Other patients respond well to the medication if it is taken only every other day, and side effects are reduced with intermittent dosing.
For treating edema associated with diabetes, the dose may need to be increased to as high as 100 milligrams per day, according to Drugs.com.
WebMD explains that hydrocholorthiazide is most commonly used to treat high blood pressure, also called hypertension. It is a diuretic, meaning that it encourages the body to produce more urine. Its diuretic properties allow it to be used to treat other conditions that lead to excessive fluid build up in the body such as diabetes.