Drug manufacturers and the medical community compare statins side by side in drug trials, according to the PubMed Clinical Q&A. Statins and combination drugs can both lower LDL cholesterol, which is the cholesterol that causes problems in the body.
There are six statin drugs in the United States as well as three additional combination drugs using statins combined with vitamin B-3 or ezetimibe, according to the PubMed Clinical Q&A. Each of these drugs has been compared against one another to find the agent most likely to work for patients. The findings have shown that atorvastatin, simvastatin, ezetimibe-simvastatin, niacin extended-release-lovastatin, rosuvastatin, and lovastatin reduce LDL-c by up to 50 percent when taken in low-dose strengths.
Ezetimibe-simvastatin 10/40mg or higher, atorvastatin when taken in higher doses of 40 to 80 milligrams, and rosuvastatin when taken in a higher dosage of 20 milligrams or more can decrease LDL-c by 50 percent or more, according to PubMed Clinical Q&A. Studies have found that the combination product known as ezetimibe-simvastatin is the most likely to reduce LDL-c by over 50 percent than any of the other statins alone. In general, these drugs also have a positive effect on HDL-c, which is the good cholesterol that is needed throughout the body.