What Is the Most Common Type of Monoclonal Protein in Multiple Myeloma?


Quick Answer

The most common type of monoclonal protein in multiple myeloma, or cancer of the plasma cells, is IgG, says Lab Tests Online. People with IgG myeloma comprise about 50 to 60 percent of the cases. Those with IgA make up 20 percent, while IgE and IgD are seldom reported.

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Full Answer

When a plasma cell becomes malignant and divides uncontrollably, it generates numerous clones of itself. Clones all produce the same antibodies or abnormal monoclonal M proteins, also called immunoglobulins. Though there are five different possible outcomes because there are five kinds of immunoglobulins – IgG, IgA, IgE, IgD and IgM – each cell can only produce one kind. While M protein varies between individuals, a person can only have one kind being produced by cloned or identical plasma cells, explains Lab Tests Online.

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