Some common connective tissue diseases include Ehlers-Danlos syndrome, epidermolysis bullosa and Marfan syndrome, according to WebMD. These diseases, along with osteogenesis imperfecta, are all heritable disorders of connective tissue and occur due to changes in the genes. Autoimmune diseases that affect the tissues are polymyositis and dermatomyositis, rheumatoid arthritis and scleroderma. Sjogren's syndrome and systemic lupus erythematosus are other tissue diseases.
Symptoms of Ehlers-Danlos syndrome include flexible joints, stretchy skin and excessive scar tissue growth, notes WebMD. Other symptoms may be bleeding gums or weak blood vessels. Epidermolysis bullosa is a result of defects in skin proteins and is usually present at birth. Extremely fragile skin that blisters or tears easily is a characteristic of the disorder. People with Marfan syndrome tend to be very tall with long bones, but it also affects the eyes, heart and ligaments.
The immune system of people with rheumatoid arthritis attacks the membrane that lines the joints and causes pain, stiffness and inflammation, states WebMD. Other symptoms are loss of appetite, fever and tiredness. Scleroderma causes thick skin that tightens, buildup of scar tissue, and organ damage. Scleroderma can be localized, which mostly affects the skin and muscle underneath, or it can be systemic, which affects the blood vessels and organs.