Wegener's granulomatosis commonly affects the sinuses, throat and lungs first, producing symptoms such as a persistent runny nose, nosebleeds, cough, and sinus pain and inflammation, notes Mayo Clinic. The condition can worsen rapidly, and people may experience symptoms such as blood in urine, fever and unintended weight loss. While Wegener's granulomatosis doesn't usually affect the kidneys in its early stages, when the kidneys do become involved, it can lead to anemia and kidney failure.
Wegener's granulomatosis is a rare disorder in which inflammation of blood vessels leads to a lack of proper blood flow to organs such as the skin, eyes, heart and kidneys, states Mayo Clinic. The condition leads to the formation of granulomas around blood vessels, which can destroy healthy tissue. Early detection of the disease is very important to ensure full recovery, as untreated Wegener's granulomatosis can lead to kidney failure and even death.
The cause of Wegener's granulomatosis is unclear, but it may be related to abnormal reactions from the immune system following events that cause inflammation, according to Mayo Clinic. The condition most often strikes those who are middle-aged, and the disorder is more prevalent among Caucasians than African-Americans. Doctors diagnose Wegener's granulomatosis by examining the patient's symptoms and medical history and ordering blood and urine tests, but a final diagnosis is only possible through a biopsy of tissue from an affected organ.