The most common medications that treat the sexually transmitted disease syphilis include doxycycline hyclate, minocycline, Doryx, and erythromycin, as reported by WebMD. These drugs are all oral antibiotics.
Syphilis is a contagious sexually transmitted disease that spreads easily through close bodily contact, as stated by WebMD. The bacteria Treponema pallidum causes the disease. Red sores develop in the early stages of syphilis; if left untreated, it can spread to the heart, brain and the nerves. If a doctor diagnoses the disease in its early stages, patients typically can take a single dose of antibiotics to get rid of their infection.