A colposcopy-directed biopsy evaluates the cervix to detect cancer or signs that lead to cancer, states MedlinePlus. Colposcopy-directed biopsies use light and a low-powered microscope to magnify the cervix and successfully perform a biopsy.
Doctors frequently use colposcopy-directed biopsies if a patient experiences an abnormal Pap smear or bleeding after sexual intercourse, according to MedlinePlus. In addition, doctors may recommend a colposcopy-directed biopsy if abnormal growth, genital warts or inflammation is detected during a pelvic exam. The possible factors that lead to abnormal test results are cervical dysplasia, cervical cancer and the human papilloma virus. If the biopsy is unable to determine the reason for the abnormal test results, a cold knife cone biopsy may be required for an accurate diagnosis.