It is recommended that consumers choose a SAM-e brand that has a good reputation, according to About.com. Since SAM-e is not regulated in the United States, caution should be used when taking it.
Those who take SAM-e should also take vitamin B supplements, states About.com. SAM-e works together with these vitamins and becomes more effective. SAM-e should only be used by individuals who are under the care of a doctor, and the dose should not exceed more than 1,200 milligrams per day.
Most people who take SAM-e take it for osteoarthritis relief, and in many cases, it may work better than traditional osteoarthritis medications, explains About.com. Research shows that SAM-e is just as effective as non-steroidal anti-inflammatory drugs when reducing pain and improving motion. It has also been found to have fewer side effects for patients. In addition, SAM-e has been shown to be just as effective as Celebrex after taking the supplement for more than two months. SAM-e, however, is slower to become effective in the first month of use for most patients.
There are side effects associated with SAM-e, warns About.com. These side effects include nausea, diarrhea, flatulence, vomiting and headache. There is also the possibility of negative interactions with antidepressants and may worsen symptoms of Parkinson's disease.