The side effects of CholestOff are primarily gastrointestinal, such as heartburn, nausea, indigestion, diarrhea or constipation, according to Sharecare.com. Decreased sexual drive and erectile dysfunction have also been reported as side effects.
The gastrointestinal side effects of CholestOff tend to be minimal. These side effects are caused by the interaction between CholestOff and cholesterol in the gut.
CholestOff supplements use plant sterols and stanols to help lower dietary cholesterol, with the aim of decreasing the risk of heart disease, according to Nature Made. One serving of CholestOff has 1.8 grams of plant sterols and stanols. Adding 2 grams of plant sterols and stanols to the diet per day can reduce low-density lipoprotein cholesterol by 5 to 15 percent, estimates the National Institutes of Health.