Cancer cells are insensitive to antigrowth signals, evade apoptosis, have limitless potential for replication and exhibit sustained angiogenesis, according to Genentech. Additional characteristics include self-sufficiency in growth signals and a proclivity to tissue invasion and metastasis.
When a healthy cell undergoes a malignant transformation, is also undergoes significant cellular changes that may signify the development of cancer, explains Genentech. Some of these changes include tumor-promoting inflammation and genome instability or a proclivity toward mutation. Additionally, cancer cells tend to exhibit sustained proliferative signaling that allows them to grow at a faster pace than healthy cells. Cancer cells also evade destruction by lymphocytes and macrophages in the immune system.