Celiac disease and other conditions that cause malnutrition usually are associated with low levels of alkaline phosphatase in the blood, according to WebMD. A high alkaline phosphatase level is more typical of liver problems or problems with the bones, WebMD states.
Alkaline phosphatase is a protein found in the liver, the bile ducts and the bones, explains MedlinePlus. Diseases, such as hepatitis, cirrhosis, bone cancer or obstructed bile ducts, that damage any of these structures tend to elevate alkaline phosphatase levels. Alkaline phosphatase also is increased in some people with lymphoma or leukemia and in people who have type "O" or "B" blood after eating a fatty meal, according to MedlinePlus.