The causes of uterine thickening include imbalance and lack of control of estrogen and progesterone hormones, and chronic diseases such as diabetes, obesity and polycystic ovarian syndrome, according to Healthgrades. Hormone imbalances caused by these diseases, or in general, can make cells on the uterus lining grow and thicken.
Uterine thickening, medically referred to as endometrial hyperplasia, is the abnormal thickening of the uterus lining prior to conception, and the lining may shed if a woman does not become pregnant, according to Healthgrades. Missed menstrual periods, obesity, diabetes, polycystic ovarian syndrome and menopause are the danger signs that a woman may be at risk of developing uterine thickening.
Estrogen builds up the uterine lining, and progesterone maintains the lining. Both hormones control menstruation, states Healthgrades. Overproduction of estrogen accompanied with less progesterone can cause the uterine lining to thicken due to excessive growth of cells. Women who undergo estrogen replacement should ensure that they balance the hormone with progesterone to avoid cancer and uterine thickening.
To control uterine thickening, women should check their menstrual cycles, control them with contraceptives and maintain a healthy weight, suggests Healthgrades. Hormone replacement therapy should be undertaken only with the guidance of a medical professional.