Skin blisters can be the result of friction, burns, contact with irritants, autoimmune diseases and infections, or they can be reactions to certain drugs, explains WebMD. There are also some rare genetic diseases that can cause skin blisters. Similarly, these causes can also lead to corns and calluses on the skin.
When exposed skin rubs against the surface of an object, the short and intense contact can result in a blister, notes WebMD. When this contact becomes prolonged, the intense, repetitive friction can result in corns and calluses. Burns, whether from the sun or direct skin contact with a hot surface or substance, can cause the formation of a blister. Similarly, contact with extreme cold surfaces can cause the same reaction. Exposure to irritants or toxins such as chemicals, makeup, or plant and animal allergens can also cause skin blisters.
Pemphigus vulgaris, bullous pemphigoid and dermatitis herpetiformisare are the three autoimmune diseases often associated with the formation of skin blisters, according to WebMD. Pemphigus vulgaris is a serious disease that causes painful blisters on the skin and in the mouth. Bullous pemphigoid is a disease commonly suffered by elderly people that causes less severe, less painful blisters. Dermatitis herpetiformisare is a chronic skin condition that results in the formation of small, itchy blisters.