The cause of Peyronie's disease is not known, explains MedicineNet. However, one possible cause is hitting or bending that results in internal bleeding of the penis. Other likely causes of the disease include vasculitis, connective tissue disorders and heredity.
Vasculitis refers to the inflammation of blood or lymphatic vessels, which leads to formation of scar tissue, notes MedicineNet. The penis can be damaged during sex, athletic activity or an accident, according to Mayo Clinic. During erection, the region with the scar tissue fails to expand, which causes the penis to bend and become disfigured. The results can also be accompanied with pain.
About 30 percent of men who suffer from Peyronie's disease develop connective tissue disorders in other parts of the body including their hands and feet. The disorders result in a thickening or hardening of the connective tissues, such as cartilage, bone and skin, which support other body tissues. Men with connective tissue disorders are susceptible to Peyronie's disease, states Mayo Clinic. For instance, many men with Peyronie's disease have Dupuytren's contracture, which is a cord-like thickening in the palm.
In addition, some studies support the idea that a Peyronie's disease patient is likely to have a relative who suffered from the same disease, reports MedicineNet.