What Causes Mantle Cell Lymphoma?

The causes of mantle cell lymphoma are unknown, states WebMD. However, most people with this condition have a common mutation in their genetic factor. This mutation prompts the body to release a protein known as cyclin D1. Excessive production of this protein results in the overproduction of a particular type of B cell, leading to mantle cell lymphoma.

Mantle cell lymphoma is a blood cancer that originates from the lymph nodes and spreads to the bone marrow and to the gastrointestinal track, according to the Lymphoma Research Foundation. This condition is rare and often affects men over 60 years of age.

Diagnosis of mantle cell lymphoma involves physical examination and several tests that include blood tests, a PET scan, a biopsy and a CT scan. A doctor performs a physical exam and asks questions concerning recent weight loss, unusual fatigue, and swelling in the groin, neck, armpits and other areas in the body. Blood tests determine the white blood cell count and disclose particular proteins in the blood that indicate cancer. A PET scan involves the use of radioactive material to check for signs of cancer, explains WebMD. A computed axial tomography and a bone marrow biopsy can confirm the diagnosis and reveal areas in the body affected by the cancer, notes the Lymphoma Research Foundation.