Dupuytren's contracture and ganglion cysts cause lumps in the palm of the hand, according to WebMD. When a person has Dupuytren's contracture, the cords in the skin tissue thicken and tighten. Ganglion cysts are tumors or swelling on top of joints or the coverings of tendons.
Lumps under the skin on the palms of the hands are one of the first symptoms of Dupuytren's contracture, notes WebMD. The condition occurs when the normally elastic tissue in the palm thickens and contracts, causing the fingers to curl toward the palm. People with the most severe forms of Dupuytren's contracture may suffer from permanent hand damage. There is no known cause of Dupuytren's contracture, as of 2015, but risk factors include excessive use of alcohol, having diabetes or seizures, and smoking. Men are more likely to develop the condition than women, and the risk increases with age.
Ganglion cysts occur most commonly on the wrist, though they may also appear on the palm below the finger joints, states WebMD. The cysts are filled with a jellylike, thick material and may appear as one large cyst or many smaller cysts that are usually connected by one stalk beneath the skin. Doctors do not know the cause of ganglion cysts, as 2015. The cysts are more likely to appear in women than men, and they occur primarily in those between the ages of 20 and 40.