Kidney disease is a notable cause of low globulin levels, according to Health News Channel. Hemolytic anemia and liver disease are other causes. Malnutrition, celiac disease and bowel inflammation also foster low globulin levels.
Health News Channel notes that kidney disease occurs when the body expels globulin and protein through urination. The glomeruli of the kidneys are responsible for filtering protein nutrients and globulin levels. When the glomeruli are suppressed through kidney infection, vital nutrients, such as globulin, are lost.
Globulin also dwells in the red blood cells. Hemolytic anemia occurs when the blood cells die faster than their lifespan of 120 days, and the body fails to produce new blood cells within this period. Globulin decreases as the blood cell count dwindles. Liver disease also kills red blood cells.
MD-Health.com mentions that renal disease and hepatic dysfunction are other causes of low globulin levels. Agammaglobulinemia and hypogammaglobulinemia are other causes. Wikipedia defines hypogammaglobulinemia as an immune deficiency that lowers gamma globulins of all types. The A.D.A.M. Medical Encyclopedia defines agammaglobulinemia as a disease passed down within families that lower immunoglobulin levels in the body. Certain neoplasms are another cause of low globulin levels in the blood, according to SteadyHealth.com.